In many unbalanced private set intersection (uPSI) applications of the client-server setting, the server needs to perform uPSI with multiple clients. Cong \textit{et al.} (ACM CCS'21) proposed a state-of-the-art (SOTA) uPSI protocol based on fully homomorphic encryption (FHE), achieving malicious security by employing an oblivious pseudorandom function (OPRF) in the pre-processing phase. However, re-executing existing uPSI protocols with each client imposes significant computational overhead for the server. In this paper, we present JAGUAR, a maliciously secure and efficient uPSI protocol designed for this setting. JAGUAR reduces online computation through a Divide-and-Combine optimization, requiring only homomorphic multiplications. Furthermore, it employs a novel fixed VOLE-based OPRF that enables reusable and lightweight pre-processing across multiple clients. Experimental results demonstrate that JAGUAR achieves up to improvement in online runtime compared to the SOTA protocol in LAN. In multi-client scenarios, JAGUAR further outperforms existing protocols by a wide margin in terms of scalability and overall performance.